Its very rarely I do any animations and especially animations that need to sync with a sound. The other day I had a small job that required this.
I set my framerate and then import sound onto the timeline and set it’s Sync property to ‘Stream’. Once the animation was complete and I tested the movie the sound quality was absolutely aweful. It just wasn’t useable at all. The problem here was that is was just a voice over. The rest of the voices overs have been added directly to a director file and they are crystal clear, so I couldn’t just have a major drop in quality on this small flash animation. I tried lots of different compression settings but none of them produced a sound that was usable (i presume if your sound is music, then the quality difference wouldn’t be so noticable).